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Are We Heading Into the Age of Personalized Medicine for Cannabis?

Matt Weeks
cannabis, prescriptions, medical cannabis, personal medicine, legalization, Canada, cannabinoids, endocannabinoid system, entourage effect, CBD, THC

The future is now for cannabis consumers! You can get a genetic report that outlines the details of your endocannabinoid system, allowing you to make cannabis a personalized medicine.

Cannabis connoisseurs spend a lot of time discussing the genetics of plants. These conversations are definitely important, as the plant strain indicates all sorts of medically and recreationally relevant information. There is, however, another dialogue about genetics that might be more important: How do your genetics affect the way you react to cannabis? And can this usher in the age of personalized medicine.

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Image credit: science photo

Genetic Testing for Your Endocannabinoid System

In the brave new world of genetic testing, doctors are increasingly using patient DNA as a determining factor for which medicines to prescribe or treatments to pursue. It is the age of personalized medicine.

Now, one company has developed the first DNA report that specifically seeks to explain the intricacies and eccentricities of a user’s endocannabinoid systems. Thanks to modern genetic sampling techniques, the company claims your DNA can show which cannabis strains and terpenes can best help you achieve your cannabis goals — whether its relaxation, sleep, pain relief or avoiding anxiety and dependence.

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Image credit: CAPJAH

While this new approach is still in infancy, the potential for credible help is undeniable. We’ve long known that the same strain of cannabis can affect consumers in different ways — and it makes sense that our genetic makeup is the cause. After all, even the Mayo Clinic supports genetic testing to help find and fight diseases. The popularity of DNA swab services, like 23andMe, have assured investors that there’s a substantial public willingness to pony up money to learn more about their chromosomes. The only question that remains is what, exactly, could be different between two people in regards to cannabis?

As it turns out, there’s a lot.

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Image credit: Dusan Petkovic

The biggest predictor of differences in people’s response to cannabis is probably the cannabinoid receptors nestled inside the endocannabinoid system. These special proteins are what interact with cannabinoids — both those the body produces naturally (endocannabinoids) and those from cannabis — to create the psychoactive and therapeutic effects that cannabis is famous for.

So Many Different Versions of CB Receptors?

So far, genetic scientists have identified nine different versions of cannabis receptor protein known as CB1. Because CB1 is the receptor that communicates with THC, variations in its architecture could be responsible for the different highs consumers experiences when using cannabis. It might even explain why some people prefer the more mellow indica strains of cannabis to headier sativa varieties.

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Image credit: CRIPOG

And CB1 isn’t the only cannabinoid receptor. Scientists have identified a second kind of receptor, known as CB2, and so far, have found four variations of it. Unlike its earlier known counterpart, CB2 doesn’t interact with THC that much. Instead, it’s what allows cannabidiol (CBD) to create relaxing and anti-inflammatory effects in the body.

There is a even a suspected third type of cannabinoid receptor, called CB3 or GPR55. It is currently under heavy research as it’s found throughout the brain and GI tract and even on the surface of cancer cells.

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Image credit: jovan vitanovski

It’s already known that there are seven variations of FAAH, an enzyme that breaks down endocannabinoids in the body, and that people with certain varieties of FAAH enzymes are affected by cannabis differently.

So, What Can We Do With This Info?

Stringing these three data points together would provide users with actionable information for medical and recreational purposes — but there’s much more to the endocannabinoid system, and the body’s reaction to cannabis, than merely those genetic markers.

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Image credit: Macrovector

For instance, the different ways of consuming cannabis may produce different outcomes based on our biology. Different enzymes in the liver could alter the way edible cannabis is processed by the body.

We already know that the liver breaks the THC in cannabis (known as delta-9-THC or Δ9-THC) into hydroxy THC (11-OH-THC), and that this simple change alone affects how the endocannabinoid system reacts. If different people break down the chemical in slightly different ways, DNA could explain how and why. It could also predict which strains would most likely to produce the best results in each patient, and which method of consumption could enhance positive effects or negate negative ones. It might mean your budtender and your doctor would need to have a meeting.

cannabis, prescriptions, medical cannabis, personal medicine, legalization, Canada, cannabinoids, endocannabinoid system, entourage effect, CBD, THC

Image credit: Africa Studio

But beyond the genetics present at birth, cannabis may also affect and/or be affected by our epigenetics. Epigenetics is the study of gene expressions that are not based on the alteration of DNA. It’s what happens when an inherited gene “turns on” or “turns off” due to environmental factors that you come into contact with during your unique life path.

It’s entirely possible — though not yet proven — that cannabis plays a role in epigenetics. It could turn on certain bodily behaviors related to relaxation or calmness or even effect how our immune system deals with inflammation. Put another way: cannabis could change your genes.

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Image credit: UGREEN 3S

But that’s all a long way off. What we know now is that we’re one day closer to understanding the link between cannabis and people on a very deep level, a personalized medicine level. How awesome is that?





Matt Weeks

A writer living and working in Athens, GA, Matt's work has appeared in various newspapers, books, magazines and online publications over the last 15 years. When he's not writing, he hosts bar trivia, plays in local bands, and makes a mean guacamole. He holds an undergraduate degree in journalism and a master's degree in organizational theory. His favorite movie is "Fletch."

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