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Avidekel Cannabis Oil In Israeli Autism Study Has 90% Success Rate!

Randy Robinson
Boy with autism staring at camera

Israeli medical cannabis firm, Tikun Olam, has completed autism clinical trial with CBD-rich Avidekel cannabis oil. The results are very hopeful for autism patients.

Media images of sick children taking cannabis oil brought medical cannabis to the mainstream. Often, the most extreme cases made the biggest impacts—Charlotte Figi, Alyssa Erwin, Haleigh Cox. While most families will never endure the trials of caring for a child with Dravet syndrome, brain cancer, or cerebral palsy, one condition could hit close to home: autism. Fortunately, the Avidekel chemovar by Tikun Olam is proven effective in treating symptoms of autism in recent clinical trial.

Small Autistic Boy With Back to Camera Sitting on a Couch

What Do Autistic Patients Experience?

Autism is a neurodevelopmental disorder that usually first appears in childhood. It’s marked by difficulties with communication, misinterpreting social cues, an unusual focus on specific interests, repetitive behavior, and outbursts known as “the rage.” Currently, medical professionals treat autism as a range of distinct, but related conditions rather than a single diagnosis. Some autistic individuals may be unable to communicate or function at all, while others with milder forms, such as Asperger’s syndrome, may excel at the workplace while still encountering difficulties with communication or maintaining relationships.

How many people live with autism? We’re not sure. US government tallies estimate anywhere between 1 in 40 to 1 in 59 people qualify as autistic. Worldwide estimates put the number at around 25 million people, although some experts suspect 50 percent of all autism cases go undiagnosed or undetected.

Close up of Avidekel cannabis plant from Tikun Olam

CBD-rich Avidekel Strain by Tikun Olam

Avidekel Chemovar by Tikun Olam

Earlier this month, the Israeli medical cannabis firm, Tikun Olam released the results of an ongoing study with autistic children and a plant the company dubbed Avidekel.

According to the study, 90 percent of patients showed improvement of symptoms after taking the oil for at least six months. Of those patients, 30 percent reported “significant improvement” while 53 percent reported “moderate improvement.” Only 8.6 percent of patients reported no improvement.

“Autism is a leading condition of concern worldwide, so this study couldn’t have come at a better time,” said Dr. Annabelle Manalo, PhD, Tikun Olam’s science director, in a press release. “The data shows that autism patients can improve their overall quality of life utilizing a [CBD-rich] strain, and most importantly, that young users can safely and effectively benefit from medical cannabis.”

Dr. Annabelle Manalo portrait

Dr. Annabelle Manalo

Avidekel Has High Success Rate For Autism Treatment

Out of the 179 patients who participated in the study, only 23 patients reported undesirable side effects. The most common side effects included restlessness, drowsiness, and increased appetite.

Success rates differed according to the patient. Of those taking antipsychotics, 23 patients decreased the amount of non-cannabis pharmaceuticals they took (antipsychotics, antidepressants, hypnotics, sedatives). Eleven patients stopped taking the other medications altogether.

Pills with no refill on the cap

Autism sometimes shares comorbidity with epilepsy, and 23 (14 percent) patients had epileptic disorders. According to the study, after six months of Avidekel treatment, eleven of these patients showed improvement in seizure occurrence, and two patients stopped experiencing seizures.

Currently, no medication exists solely to treat autism. Doctors consider it incurable, although many autistic individuals do not consider their condition a disease that requires curing. Regardless, psychological therapies serve as the most common method for treating autism, along with pharmaceuticals like antipsychotics and mood stabilizers. Unlike cannabis, these drugs often come with a slurry of side effects, including but not limited to shakiness, constipation, mood swings, or an increased risk of diabetes.

blank cartoon figures and one like a colorful puzzle figure

Some Participants Saw Additional Improvement With Added THC

According to its pending patent, Avidekel produces a relatively high amount of CBD (16.3 percent by dry weight) and an incredibly small amount of THC (0.8 percent by dry weight). The typical oil employed in Tikun Olam’s study contained 30 percent CBD and 1.5 percent THC dissolved in olive oil. Patients or their parents titrated the doses on a case-by-case basis.

Some patients, such as those with sleep issues or aggressive behavior, received an added 3 percent THC oil.

The inclusion of THC to the treatment regimen may account for Avidekel’s success. CBD possesses a higher affinity – or “stickiness” – to CB2 receptors, protein signaling channels found most abundantly on immune cells. THC, on the other hand, possesses a higher affinity for CB1 receptors, which are most concentrated on nerve cells in the brain and in the spinal cord.

Animation showing how THC binds to CB recptors

Avidekel Has No Issues With Building Tolerance

Although CBD can treat neurological conditions such as seizure disorders and autism, patients may develop a tolerance to pure CBD, requiring greater amounts over time to achieve the same results. However, combining CBD with small amounts of THC appears to resolve tolerance issues—as seen in this study.

In an email to RxLeaf, Manalo noted that patients took well to the CBD-to-THC combination. “Patients did not undergo any medication tolerances,” she wrote. “As we followed these patients for 2 years, the treatment became more beneficial over time in a majority of children.”

Tikun Olam’s team speculates that other compounds besides CBD and THC may be involved, too. CBG, CBN, CBC, and CBDV were also detected in the oils, though at relatively low amounts (from less than 1.5 percent to less than 0.5 percent). The most prominent terpenes found in Avidekel include beta-myrcene, alpha-pinene, limonene, and beta-pinene, according to Manalo.

Achronym for autism Always Unique Totally Interesting Sometimes Mysterious

Israel: Leagues Ahead of the World in Cannabis Research

As medical science gets better at recognizing autism, the pharmaceutical technologies for treating the condition must improve at the same pace. As researchers struggle to design drugs for autism, the most effective and safe one may be stuck under severe legal restrictions and social stigmatization.

Israel, where Tikun Olam is based, could be considered the world leader in medical cannabis research. The Israeli government directly funds research, and government medical programs often coordinate with universities and private companies to develop and dispense cannabis-based medications.

Will Canada and the US catch up soon? Let’s hope so, because for patients and their families, time isn’t something they can spare.

 

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Randy Robinson

As someone who wanted to know everything but couldn't decide on anything, Randy completed degrees in English, World History, and Molecular Biology. During their studies, they received an externship at the biotech firm Cannabis Science Inc., focusing on phytocannabinoids as anti-tumor and anti-cancer agents. Based in the Mile High City of Denver, Colorado, you can find Randy on Twitter, Instagram, and Medium @RanDieselJay

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