Cancer Metastasis May be Stopped by CBD and THC

Christine Kielhorn PHD July 15, 2018 15 comments

Study shows there is potential that the CBD and THC in cannabis possibly slows, and even prevents, tumor metastasis.

As science continues to further study the effect of cannabinoids on cancer cells, researchers are finding that CBD and THC in cannabis potentially slows or prevents tumor metastasis. This is especially good news, since metastasis if the final stage of cancer, and it can often be fatal. Keep in mind, the following research is at a very early stage. More research will come on the subject soon.

The process of metastasis is a devastating one. Cancer cells escape the tumor and begin invading tissues and organs. These cells can then travel through the blood stream or lymph nodes to other areas of the body. And while doctors can in some cases treat metastasis, the survival rate is significantly lower than earlier stages of cancer.

When confronted with metastasis, doctors attempt to slow the growth of the tumor and prevent migration of cancer cells to the liver, lung or brain. However, some cancers metastasize more aggressively than others, making them more difficult to treat.

Cannabis May Slows Or Prevents Cancer Cell Metastasis

Studies are now showing the potential for cannabinoids such as CBD and THC to slow the growth of tumors. While it’s too early to definitively say “cannabis prevents metastasis”, there is a hope of this coming about eventually. In this study published in the Journal of Neuroimmune Pharmacology (2015), 1)McAllister, et al. “The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids, Journal of Neuroimmune Pharmacology.” DeepDyve, Springer US, 28 Apr. 2015, www.deepdyve.com/lp/springer-journals/the-antitumor-activity-of-plant-derived-non-psychoactive-cannabinoids-cmxY2L7Aev. researchers discovered that cannabinoids could block angiogenesis, which is the process by which new blood vessels form. This was made possible through the ability of cannabinoids to reduce expression of the ligand and its associated receptors in the vascular endothelial growth factor (VEGF) pathway.

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This pathway plays a major role in tumor growth, which is why the findings of this study are so promising for cancer research. By targeting this pathway, cannabinoids can inhibit angiogenesis and tumor growth. This in turn could help improve survival and response rates in cancer patients.

Inhibiting the VEGF pathway prevents tumors from growing new blood vessels, which are what feeds a tumor’s out-of-control growth. This study showed that CBD has the potential to treat different types of cancer, including prostate, lung, breast, and colon cancer. An even earlier study published in Oncology Reports (2006) 2)Bifulco, et al. “Endocannabinoids as Emerging Suppressors of Angiogenesis and Tumor Invasion (Review), Oncology Reports.” DeepDyve, Spandidos Publications, 1 Apr. 2007, www.deepdyve.com/lp/spandidos-publications/endocannabinoids-as-emerging-suppressors-of-angiogenesis-and-tumor-Q1vjg0toyS.

also found that THC and CBD could potentially be used to shut down the process by which cancer spreads throughout the body.

white woman cancer patient who probably hopes cannabis prevents metastasis

CBD May Slow Glioma Tumors

In this 2005 study published in the British Journal of Pharmacology, 3)Vaccani, et al. “Cannabidiol Inhibits Human Glioma Cell Migration through a Cannabinoid Receptor‐Independent Mechanism, British Journal of Pharmacology”. DeepDyve, Wiley Subscription Services, Inc., A Wiley Company, 1 Apr. 2005, www.deepdyve.com/lp/wiley/cannabidiol-inhibits-human-glioma-cell-migration-through-a-cannabinoid-gR0oEi08du. scientists also discovered that CBD could potentially inhibit glioma cell migration. Glioma tumors typically grow and spread aggressively and quickly, making them difficult — or impossible — to remove surgically.

Researchers found that CBD could inhibit the production of metalloproteinases (MMPs). Through a process of breaking down components of the extracellular matrix, these proteins support the development of tumor blood vessels and aid the migration of cancer cells throughout the body. Essentially, these proteins create the opportunity for cancer cells to escape the tumor.

Once the cancer cells have escaped, they need a getaway vehicle. That’s where adhesive proteins like focal adhesion kinases (FAKs) come in. These promote metastasis by allowing cancer cells to easily migrate to other organs and areas of the body.

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What About Cancer Cell Migration?

This study in Current Oncology (2016) 4)Velasco, G, et al. “Anticancer Mechanisms of Cannabinoids.” Current Oncology (Toronto, Ont.), Multimed Inc., Mar. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4791144/. found that cannabinoids could inhibit FAKs in cancer cells in mice, thereby taking away their ability to migrate. Researchers also found that THC could potentially promote cell death through activating CB1 and CB2 receptors. But that’s not all they found. Scientists also discovered that THC can produce a shift of the cytokine profile and stimulate mobilization of myeloid-derived suppressor cells, thereby regulating anti-tumor immunity.

In addition, researchers have discovered that CBD has the ability to turn off the body’s Id-1 gene in breast cancer. This pro-metastatic gene is what makes this type of cancer so aggressive. By turning off this gene, CBD also promotes inhibition of other genes that also promote metastasis. Through slowing or preventing the spread and growth of breast cancer cells, this treatment could save a considerable number of lives.

x ray from doctor who probably hopes cannabis prevents metastasis

The Future of Cannabinoid Cancer Treatment

Along with the potential ability of cannabinoids to slow cancer growth, scientists have been encouraged by the low toxicity of cannabis — particularly CBD. More than the toxicity profile looks promising, too. Researchers have found that it’s possible CBD could work alongside other medications and treatments without interfering.

Along with THC and CBD, researchers are also delving into the potential cancer-fighting abilities of terpenes and flavonoids. For instance, scientists have explored myrcene’s ability to also stimulate cancer-cell death and inhibit metastasis.

Granted, much of the existing cannabinoid-cancer research is conducted on lab mice or in vitro. But nevertheless, these results are incredibly promising, and pave the way for more research in the future. With additional studies and human trials, it’s possible that scientists could turn cannabis into a medicine that treats and prevents metastasis. And, if cannabis can indeed inhibit this final, fatal stage of cancer to progress, the potential for survival from aggressive cancers could be profound.

References   [ + ]

1. McAllister, et al. “The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids, Journal of Neuroimmune Pharmacology.” DeepDyve, Springer US, 28 Apr. 2015, www.deepdyve.com/lp/springer-journals/the-antitumor-activity-of-plant-derived-non-psychoactive-cannabinoids-cmxY2L7Aev.
2. Bifulco, et al. “Endocannabinoids as Emerging Suppressors of Angiogenesis and Tumor Invasion (Review), Oncology Reports.” DeepDyve, Spandidos Publications, 1 Apr. 2007, www.deepdyve.com/lp/spandidos-publications/endocannabinoids-as-emerging-suppressors-of-angiogenesis-and-tumor-Q1vjg0toyS.
3. Vaccani, et al. “Cannabidiol Inhibits Human Glioma Cell Migration through a Cannabinoid Receptor‐Independent Mechanism, British Journal of Pharmacology”. DeepDyve, Wiley Subscription Services, Inc., A Wiley Company, 1 Apr. 2005, www.deepdyve.com/lp/wiley/cannabidiol-inhibits-human-glioma-cell-migration-through-a-cannabinoid-gR0oEi08du.
4. Velasco, G, et al. “Anticancer Mechanisms of Cannabinoids.” Current Oncology (Toronto, Ont.), Multimed Inc., Mar. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4791144/.

15 comments

  1. Avatar

    Stephen King

    Who did this study, and what are the names of the journal articles?

    • Jennifer Grant

      Jennifer Grant

      Hi Stephen – if you look back in the article, you will see text in a different color. These are links to the studies and/or more related information.

  2. Avatar

    josh

    Careful with your titles if you wouldn’t mind. That’s a bold statement and quite misleading. It MAY inhibit CERTAIN metastasis…lab results are a world away from being effective in the human body.
    Don’t think it’s responsible to make things sound absolute and definitive when at this stage of research.

    • Jennifer Grant

      Jennifer Grant

      Thanks Josh. Multiple lab studies demonstrate this ability of cannabinoids to block angiogenesis and inhibit focal adhesion kinases to stop out of control growth and migration (i.e. multiple types of cancer). Multiple rodent studies have demonstrated tumor shrinkage and cancer cell death due to the blocking of these mechanisms of angiogenesis. Human Glioma studies have shown cannabinoids can block the action of MMPs, which cancer needs to leave the site and metastasize. I feel confident that the title reflects the state of cannabis and cancer research as it sits today.

  3. Avatar

    Chris turner

    I have stage four prostate cancer. I’m only 58. Treatment isn’t working. Where do I get cannibas oil

    • Avatar

      Jim Brown

      Cannibas oil has helped fight off my prostate cancer but adding to it the NORI protocol has brought my numbers down. Google NORI

    • Hi Chris! I’m sorry to hear that but there is hope!! But When looking to purchase CBD they are not all created equal. Some are mix with other byproducts or just not pure. Make sure it’s pure and lab tested. Kannaway is the first company to triple lab test all their products, they are the first to have won the hemp seal of authority, they won a bronze and silver stevi award and have strict guidelines from seed to oil . So if you are looking for the Rolex of CBD , I recommend looking into this company. Here’s the website if you want to learn more about the company or purchase
      https://kannaway.com/4488852

      • Avatar

        Jayne Bolger

        Hi
        Look at Grace’s London, they do cbd products, great back story to the company, done with the intent to help others. Also they were just featured in Forbes magazine this week.

        Good luck and hope you best this disease.

    • Avatar

      Billy Franklin

      Chris, I hope you’re doing well. Go to a fully legal state. Get a suppository.

      Research rick Simpson oil.

      Good luck sir

  4. Avatar

    Kenneth E Wright

    I have metastatic cancer from my kidney to my spine had a large amount of tumor removed from L4 it’s a clear cell carcinoma. Aggressive talking about radiation I know it’s very aggressive cancer and I’m not getting a whole lot good answer on life expectancy

    • Jennifer Grant

      Jennifer Grant

      Really sorry to hear this new, Kenneth. This must be a scary time for you and your loved ones. They’re not likely to give you life expectancy because it varies based on a lot of things (overall health, genetics, prior surgeries, treatment, mental attitude, etc). Fight with everything you’ve got. We’re rooting for you!

  5. Avatar

    Kentavious Taylor

    I don’t have cancer but suffering from Arthritis and other inflamatory ailments. I used Rick Simpson oil which contains both THC and CBD. I had noticeable effects literally the next day!!! After a week I am a total believer in the healing qualities of this stuff!!! Anything that works this well wouldn’t surprise me if it cured cancer.

  6. Avatar

    Jennifer

    It is proven fact that cannabis kills cancer but big pharm dnt want u to know that !!! RAO is the best ????????

  7. Avatar

    Anna desimone

    I am writing on behalf of my brother. He was diagnosed with stage 4 colon cancer two years ago. Had two surgeries and did chemo on and off for 2 year. Cancer is now in liver and he’s been doing RSO. would you know what strains are best to treat cancer and what to use to help I
    Prove anxiety and depression.

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