Cannabis is the Only Plant To Make THC But Others Make CBD - RxLeaf

Cannabis is the Only Plant To Make THC But Others Make CBD

Randy Robinson
cannabis, black truffles, cannabinoids, phytocannabinoids, endocannabinoid system, Canada, USA, legalization, THC, CBD

There are many, many plants that contain cannabinoids, some that are psychoactive, many that are healing, and all interact with your body’s endocannabinoid system.

Cannabis is hands-down the best source for phytocannabinoids, or plant-based cannabinoids. THC, for instance, can only be found in the Cannabis sativa plant. In the right chemovars, it’s found in abundance.

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But despite their namesake, cannabinoids as a chemical class aren’t exclusive to the cannabis plant. The name “cannabinoid” does not indicate a compound that comes from weed. Rather, it denotes a particular chemical structure similar to cannabinoids like THC. Other chemicals, called cannabimimetics, mimic the activities of cannabinoids, often by also interacting with CB receptors.

So it stands that other plants besides cannabis contain cannabinoids and/or cannabimimetics as well. These include hops, cacao, echinacea, Japanese liverwort, New Zealand liverwort, black pepper, maca, flax seeds, electric daisy, helichrysum, heliposis, Chinese rhododendron, kava, and black truffles (a fungi, not a plant, but whatever).

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This list is in no way complete. There are over 390,000 species of plants around the world, and scientists discover new ones every day. Furthermore, the details here may also be incomplete, as plants can contain thousands of different kinds of molecules within a single specie.


The plant responsible for the world’s chocolate may contain trace amounts of anandamide, a cannabinoid produced by our own bodies that may mimic the effects of THC. Our body’s natural evolution to produce and utilize anandamide may explain why we get high from THC.

Black Truffles

These expensive but rich morsels may also contain anandamide, just like cacao. Combine chocolate truffles with black truffles to create the double truffle, a succulent treat that may provide some health benefits.

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Almost every medicine cabinet with herbal supplements includes a bottle of echinacea. The herb is also found in teas designed to sooth the mind and body. This sweet flower produces a class of compounds called N-acyl amides, which can stimulate our CB2 receptors much like CBD. And like CBD, they can regulate and dampen inflammation.


An India-based company, ImmunAG, claims it bred a variety of hops it calls Humulus kriya. According to the company, because hops belongs to the same Cannabacae family as cannabis, it can be crossbred to produce CBD. This hops-derived CBD is used to make an oil that is entirely legal in the U.S. because it isn’t extracted from cannabis. However, some scientists have challenged ImmunAG’s claims and are requesting proof, since wild-type hops does not produce CBD.

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Japanese Liverwort

Isoperrottetin A was first extracted from Japanese liverwort in the 1990s. Although it is a cannabinoid by chemical structure, research hasn’t confirmed whether it possesses endocannabinoid system activity.

New Zealand Liverwort

Like its Japanese cousin, New Zealand liverwort also contains a cannabinoid with a similar name, perrottetinene. A 2018 study suggests perrottetinene interacts with the CB1 receptor, and besides having some anti-inflammatory properties, can also get people high.

Black Pepper

Yes, the same stuff you can find in your kitchen pantry. Black pepper contains at least two cannabinoids: beta-caryophyllene (also found in carrots and other veggies) and guineesine. Beta-caryophyllene, like many cannabinoids, has anti-inflammatory effects. Guineesine is a cannabinoid uptake inhibitor, and may be one of the molecules responsible for black pepper’s ability to offset a bad reaction to THC.

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Maca Root

Maca contains compounds called macamides, which can mimic phytocannabinoids by activating CB receptors.

Flax Seeds

Flax seeds and their oils have long been known to offer beneficial health effects. The fibers from these seeds produce a terpenoid that features a chemical structure like CBD’s. This mystery compound also appears to activate CB2 receptors.

Electric Daisy

Acmella oleracea, also known as the toothache plant for its ability to soothe tooth pain, produces a class of cannabimimetics called N-isobutylamides. These cannabimimetics activate CB1 receptors, which would explain why they can control pain.

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A species of sunflower, this plant produces CBG or cannabigerol. CBG is also found in cannabis, and it’s the precursor to both THC and CBD. When cannabis produces THC or CBD, it does it by first making CBG, then uses enzymes to convert CBG into one of the two primary phytocannabinoids. CBG possesses many of the same properties as THC and CBD, such as being an antibiotic, anti-inflammatory, and anti-cancer agent. CBG may also fight Huntington’s disease and help athletes build muscle.

Chinese Rhododendron

This Chinese herb has been part of the Chinese pharmacopeia for centuries, but scientists didn’t understand why until several years ago. Chinese rhododendron contains chromane and chromene type compounds that exhibit cannabinoid-like activity, and these molecules may be why this herb’s extract has antibacterial and anticancer properties.

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Image credit: Ana-Maria Oprisoreanu

Kava Root

If you’ve ever eaten or drank kava extract, then you probably experienced a heavy-headed sleepy feeling similar to a cannabis high. That could be due to yangonin, a cannabinoid found in the root that selectively binds to the CB1 receptor.

Best of All? This is Entirely Legal

In the U.S., the Controlled Substances Act only bans cannabinoids that are extracted from Cannabis sativa. If cannabinoids or cannabimimetics come from any other plant source, they’re considered legal.

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That means you can legally get intoxicated on kava root or New Zealand liverwort without worrying about the cops knocking down your door. Or you can enjoy the benefits of CBD by consuming flax seeds or flax seed oil without ever worrying about ordering questionable CBD oil online.

Now, if we can just find another plant that produces THC….

Randy Robinson

As someone who wanted to know everything but couldn't decide on anything, Randy completed degrees in English, World History, and Molecular Biology. During their studies, they received an externship at the biotech firm Cannabis Science Inc., focusing on phytocannabinoids as anti-tumor and anti-cancer agents. Based in the Mile High City of Denver, Colorado, you can find Randy on Twitter, Instagram, and Medium @RanDieselJay

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