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CBD Stops Breast Cancer From Achieving Metastasis In Recent Study

Matt Weeks
Breast Cancer showing metastatis

CBD is the first outside agent that is capable of regulating Id-1 in human breast cancer cells; blocking this function can stop metastasis.

The worst stage of breast cancer is the last one.

Once the cancer has metastasized and spread throughout the body, the end is near—and very, very painful. However, a new therapy that utilizes cannabidiol (CBD) has shown promising results in turning back the clock on invasiveness of late-stage breast cancer.

breast Cancer cells in 3-D Illustration

Image Credit: Giovanni Canceni

In a study funded in part by National Institutes of Health, molecular biologists at the California Pacific Medical Center performed tests on human breast cancer cells that reveal how CBD could slow down and even halt the progression of the disease, even at its more virulent late-stage existence.

For breast cancer sufferers, this is huge news. Despite the overwhelming public support of breast cancer patients and sky-high donations to specifically focused charities like the Susan G. Komen Foundation, breast cancer remains an insidious killer. The American Cancer Society that the average American woman has a 12 percent chance of developing breast cancer in her lifetime—more than any other cancer besides skin cancer.

Cancer cell growth

Image Credit: Gritsalak Karaiak

According to BreastCancer.org, about 266,000 new cases of breast cancer will be diagnosed in women and 2,500 cases for men in the United States this year alone. In the same time frame, the disease will kill nearly 41,000 American women.

One reason it’s so deadly is that breast cancer is often incurable once it metastasizes and moves beyond the breast tissue into other parts of the body. That’s because the final stage of the cancer’s life is least medically understood, and therefore nearly untreatable. The new CBD findings, however, are giving scientists a new avenue of inquiry.

Beast Cancer Micrograph

Image Credit: David Litman

Years ago, medical researchers discovered that a specific protein called Id-1 was responsible for much of the progressive and invasive behavior of breast cancer in its later stages. Using experiments on mice, researchers discovered that by downregulating this protein, the cancer become far less aggressive. In other words, blocking Id-1 from functioning could prevent breast cancer from metastasizing.

But there was a problem—a big one. In the mouse study, scientists used a special kind of gene therapy called antisense to de-activate the Id-1 protein, but the same kind of therapy is not possible for humans. So researchers needed a different kind of agent that would produce the same results, but could be used on people.

Breast Cancer MRI

MRI Showing Stage I Breast Cancer. Image Credit: Jane Rix

Further complicating matters, any new agent would not only have to be able to inhibit the Id-1 protein, it would have to be non-toxic and with low side effects so that it could be used on cancer patients whose immune systems are already weakened.

Luckily, cannabis stepped up.

CBD, one of the active ingredients in cannabis, is a low-toxicity, non-psychotropic molecule that affects the human endocannabinoid system. It doesn’t get patients high. Instead, it interacts with the endocannabinoid system in a number of ways, many of which are still being discovered.

CBD chemical formula beside a woman blurred holding up cannabis leaf

Image Credit: Lifestyle Discover

The California scientists knew from prior research that CBD inhibited breast cancer metastasis in mice, but the exact mechanism by which is happens is largely unknown. The scientists hypothesized that CBD may work like the antisense treatment and produce results by altering the expression of the Id-1 protein in the cancer cells—and they were right!

In a massive breakthrough, the researchers showed that CBD is the first outside agent that is capable of regulating Id-1 in human breast cancer cells. This paves the way for new and exciting therapies for even the sickest cancer patients.

Breast Cancer showing metastatis

Image Credit: Science Pics

If breast cancer can be prevented from metastasizing or halted early in its tracks, the number of lives saved could be massive. That’s not just good news for women or those with a family history of breast diagnoses—it’s good news for everyone.

Almost 85 percent of breast cancer diagnoses occur in women without a family history of the disease. And while American women have a 1 in 8 chance of developing breast cancer at some point during their lives, men are also at risk. Current data suggest that about 1 out of 1,000 men living in the U.S. will develop breast cancer.

Cannabis field through fish eye lens

Image Credit: Jiri Vaciavek

And the benefits of a CBD-based cancer therapy are most likely not limited to breast cancer. The scientists who discovered the effects of CBD on Id-1 are optimistic that new and better drugs for patients with all kinds of cancer can be created based off of this initial finding.

Imagine—if modern medicine can prevent cancer from turning into its final and most lethal form, we could grant many more years of life to millions of people across the world. All of it thanks to one little plant.

 

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Matt Weeks

A writer living and working in Athens, GA, Matt's work has appeared in various newspapers, books, magazines and online publications over the last 15 years. When he's not writing, he hosts bar trivia, plays in local bands, and makes a mean guacamole. He holds an undergraduate degree in journalism and a master's degree in organizational theory. His favorite movie is "Fletch."

24 Comments
  • Avatar
    jolene

    I was just diagnosed with lung cancer stage 3. I wonder if this CBD would help me. I don’t want chemo.

    February 13, 2019 at 4:51 pm Reply
    • Avatar
      Roger Nilsson

      It might. Look into RSO (also called FECO) and start building up a tolerance quickly.

      March 6, 2019 at 1:14 pm Reply
    • Avatar
      Binta Davis

      I was diagnosed with DCIS stage 0. I had no idea there are so many types of CBD oil. What’s the best type for me?.
      Thank you!!!

      July 3, 2019 at 2:15 am Reply
      • Avatar
        Keri Cheifetz

        I would look for one that is made with liposome technology for increased bioavailability and always ask for third party testing and a certificate of analysis.

        August 15, 2019 at 2:01 am Reply
    • Avatar
      Sharon

      Go on cureyourowncancer.org do research on Cannibis oil for your cancer

      August 16, 2019 at 12:01 pm Reply
    • Avatar
      M. Cyr

      Google provided many links, including:
      https://www.cureyourowncancer.org/the-sharon-kelly-story-how-she-beat-her-lung-cancer-with-cannabis-oil.html
      Also, look: Rick Simpson oil for cancer,
      and,
      Lung Cancer + vitamin D, B deficiency
      Wishing you a speedy recovery

      August 24, 2019 at 3:02 pm Reply
  • Avatar
    Carol Crane

    I was diagnosed 3 years ago with DeNovo Stage IV Metastatic Breast Cancer, will CBD oil help me since I was initially diagnosed with Metastatic ? Had spread to my lungs, liver and bones. I am currently NEAD ( No Evidence of Active Disease.) I’m on the oral meds Ibrance and Letrozole.

    ,

    February 16, 2019 at 1:03 am Reply
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      Frances Lynn Young

      I have the same now and dont know how to take CBD oil or Frankincense? Frances

      April 7, 2019 at 12:02 pm Reply
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        Kamila

        I suggest both! CBD and Frankincense Essential Oil (must be therapeutical value). They are excellent fighters with cancers

        August 15, 2019 at 12:32 pm Reply
        • Avatar
          Deborah Obsnuk

          How much CBD n how much frankincense daily? Internally or externally or both

          August 24, 2019 at 10:39 am Reply
  • Avatar
    Lawrence Goodwin

    Scientific research focused on the seedless, female flowers of cannabis plants should have exploded 30 YEARS ago, after the decisive September 1988 recommendation made by Judge Francis Young for the federal Drug Enforcement Administration (DEA). After months of intensive study, Young concluded that cannabis flowers are “…far safer than many foods we commonly consume” and “one of the safest therapeutically active substances known” to medicine. The compounds “cannabidiol (CBD),” “tetrahydrocannabinol (THC)” or any of the other “cannabinoids” very well may prove to be the “cure” for cancer that so many Americans have been looking for all this time.

    The main problem is that heartless DEA bureaucrats, and their arrogant protectors in the U.S. Congress, refuse to repeal the criminal Schedule I classification of “marihuana.” As of early 2019, Senate Majority Leader Mitch McConnell (R-Kentucky) is the most ruthless obstructionist in that effort. McConnell alone is prolonging one of the biggest scandals in American history.

    March 2, 2019 at 7:26 pm Reply
  • Avatar
    S.R. Claytor

    My wife was just diagnosed with Metaplastic BC. Could she benefit from this?

    March 7, 2019 at 4:03 pm Reply
    • Avatar
      Keri Cheifetz

      I see this question was awhile back. Do you still need answers.

      August 15, 2019 at 2:03 am Reply
  • Avatar
    Anne

    How is the oil used. Applied topically or injected?

    August 15, 2019 at 6:41 am Reply
    • Jennifer Grant

      For this study, all cannabinoids were taken internally.

      August 15, 2019 at 8:32 am Reply
  • Avatar
    Nereida

    Thank you

    August 16, 2019 at 10:14 pm Reply
  • Avatar
    Kim bly

    Anyone used and had success with neurofibromas who have neurofibromatosis?

    August 18, 2019 at 12:26 am Reply
  • Avatar
    Shannon Bigler

    Was the study done with isolate CBD and what dose/quantity for humans would be compatible to what mice received? My mom is currently taking a therapeutic grade isolate CBD 1000mg 10 drops two times per day since April 2019 for some of her other health issues. She was diagnosed with breast cancer Jan 2016 I just wanted to see if she is taking enough of a comparable dose to what success you saw in mice during the study. Thank you in advance for responding. Such important research needs to be available to all diagnosed.

    August 18, 2019 at 2:47 pm Reply
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    JoHanna G

    I have cbd oil and multiple sclerosis. Any thought last or dosages on that? It’s very expensive but the ms drugs r deadly.

    August 21, 2019 at 10:13 am Reply
    • Jennifer Grant

      Hello JoHanna – unfortunately, we have not advanced to the point of dosage recommendations for ANY conditions. Those who don’t want to wait for human clinical trials to be done are doing trial and error. Start low and slowly increase until you see symptom relief.

      August 21, 2019 at 3:29 pm Reply
  • Avatar
    Bruce Cornwall

    Hi Matt,

    Could you send me the reference for the medical journal article from the California Pacific Medical Centre? APA would be great, or enough info for me to source it please? Btw Great stuff, thanks

    August 26, 2019 at 8:17 pm Reply
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    Reza Singh

    Don’t rely on CBD oil entirely! In order to treat cancer, one should use RSO (Rick Simpson oil) with a high THC content (min. 80% or higher). It can be ingested by month or via suppositories. RSO is not sold by Rick Simpson himself, and he recommends that you make it yourself from cannabis buds of the Indica strain (with a high THC content). He says that anyone who claims to sell RSO should be regarded with caution- and that at the very least, the product they are selling should be analysed by an independent laboratory.
    For more information, Rick Simpson’s official website is:
    http://ricksimpsonofficial.com/producing-the-highest-quality-oils-possible/

    August 29, 2019 at 7:24 am Reply

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