Flavonoids: That Thing You Didn't Know About Cannabis - RxLeaf

Flavonoids: That Thing You Didn’t Know About Cannabis

Randy Robinson
cannabis plants

You can’t avoid flavonoids so you may as well learn about them.

If you’ve kept up with the cannabis lingo, you’re probably familiar with cannabinoids and terpenes by now. Cannabinoids are a class of compounds found in cannabis that plug into our endocannabinoid system, which regulates our body’s natural balance. Terpenes, known for giving cannabis its distinctive aromas and flavors, confer their own health benefits, and they may affect the kind of high we experience from the cannabinoids such as THC.

Cannabis but resting on pine

Image Credit: Roxana Gonzalez

Get ready for the next big thing in cannabis chemovars: flavonoids. Flavonoids are another class of chemical found in cannabis. They’re responsible for the plant’s pigments: green, purple, or blue. Roughly 20 types of flavonoids have been detected in cannabis, and they comprise about 10 percent of the plant’s total biochemical output. Over 6,000 flavonoids exist in nature, primarily plants and fungi.

Image Credit: Bilanol

Why should you know about flavonoids? For one, scientists suspect they interact with cannabinoids and terpenes as part of cannabis’ entourage effect. And like cannabinoids and terpenes, flavonoids also plug into CB1 and CB2 receptors, suggesting they contribute to the moods associated with cannabis’ psychoactivity.

Additionally, science has long established the health benefits offered by flavonoids. The benefits studied so far largely focus on orally ingesting flavonoids (think: edibles); whether these same benefits carry through inhalation (smoke) hasn’t been thoroughly investigated.

Cannabis Plants perspective looks like a forest

Image Credit: Cascade Creatives

Now, before we go any further, know that the science of flavonoids in cannabis is still in its infancy. Restrictive scheduling for cannabis has obstructed research efforts, but as legalization continues to sweep the world, we’ll slowly achieve a better understanding of what’s going on here.

But, for now, here are some potential health benefits from our favorite flower’s flavonoids.

Flavonoids, in general, tend to exhibit a few medicinal properties. They’re usually powerful antioxidants, which can prevent premature aging by protecting cells from oxidative damage. They tend to make things difficult for tumors and cancers by either slowing or preventing cancerous growth. Luteolin appears to weaken cancer cells so they’re more susceptible to chemotherapies. Silymarin particularly targets the liver and may prevent renal damage and renal cancers while also reducing the body’s insulin resistance. Several flavonoids found in cannabis, such as kaempferol, quercetin, apigenin, and genistein, are known to induce apoptosis in cancer cells – meaning they cause the cancerous cells to self-destruct (while leaving nearby healthy cells intact).

Cancer Cell in Human Body

Image Credit: Crevis

Flavonoids can also “stick” to opioid receptors just as they can CB receptors. Opioid receptors, which bind opioid drugs such as a hydrocodone or oxycontin, trigger powerful pain-killing effects in the body. While most flavonoids bind weakly to opioid receptors, some such as vitexin, isovitexin, and cannaflavin bind strongly enough to activate opioid signaling. In fact, cannaflavin is believed to be more effective than aspirin at controlling minor aches and pains.

Aspirin on a wood floor

Image Credit: Spaxiax

Other flavonoids possess unusual, novel characteristics. Take olivetol. Oddly enough, olivetol is a molecule commonly used to make synthetic THC in laboratories. The irony of olivetol being a precursor to THC is that olivetol blocks CB from interacting with other chemicals (like THC). Concentrated doses of olivetol (such as those found in Undoo pills) may alleviate anxiety during a high-gone-wrong. It’s possible that some cannabis strains known for helping patients feel extremely chill may contain higher amounts of this flavonoid.

Anxiety Woman Sillouette

Image Credit: Mike Dotta

Genistein and kaempferol, mentioned earlier, inhibit the breakdown of anandamide, one of our endogenous cannabinoids. Anandamide is chemically similar to THC, and it’s possible these two flavonoids could prolong the elevating effects of THC or anandamide. Cannabis strains that cause long-lasting highs may contain higher amounts of kaempferol or genistein.

And last but not least, some flavonoids do it all. Orientin, for instance, has antioxidant, anti-cancer, anti-inflammatory, anti-bacterial, anti-viral, and antioxidant properties. It protects the brain and nerve cells while conferring cardiovascular protections, too. Quercetin fights breast cancer, reduces inflammation, and, according to one Japanese study, removes plaque from arteries, the kinds of plaque responsible for heart attacks.

Close up of man clutching chest heart attack

Image Credit: Shutterstock

Keep in mind cannabis is not the sole source of these flavonoids, like it is with THC. Rather, these flavonoids are found in fruits, vegetables, flowers, herbs, and roots all over the world. Indeed, the reason fruits and vegetables and herbs help us stay healthy is precisely because they contain abundant amounts of flavonoids. However, most studies never looked at whether flavonoids are beneficial if smoked or vaporized. For now, your safest bet for getting the most out of flavonoids is to ingest infused edibles made from whole-plant extracts (cannabutter, infused cooking oils, Phoenix Tears oil, etc.).


Randy Robinson

As someone who wanted to know everything but couldn't decide on anything, Randy completed degrees in English, World History, and Molecular Biology. During their studies, they received an externship at the biotech firm Cannabis Science Inc., focusing on phytocannabinoids as anti-tumor and anti-cancer agents. Based in the Mile High City of Denver, Colorado, you can find Randy on Twitter, Instagram, and Medium @RanDieselJay

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