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Finding the Best Terpenes for Anxiety is All in The Strain

Jessica McKeil
cannabis, terpenes, entourage effect, myrcene, limonene, trans-nerolidol, anxiety, mental health, panic attack, legalization

Limonene, mycrene, and trans-nerolidol are three of the top terpenes for anxiety. Strains high in these medicinal gems will help keep your anxiety in check and your stress response down.

Anxiety is a society-wide mental health issue, reaching epidemic portions. Some of the latest data indicate 10 percent of the American public suffer from some type of anxiety, yet this condition rarely gets enough attention in the media and in the research.

cannabis, anxiety, terpenes, cannabinoids, endocannabinoid system, entourage effect, anti-anxiety, mental health, legalization, mental illness

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Even people suffering from an anxiety disorder tend to brush it off, after all, it’s just stress, right? Many people still refuse to seek treatment or may believe that their mental health issues are not significant enough to require treatment. These people erroneously believe that they should just be able to cope with “stress.” The difference is that stress is a response to a threat and anxiety is the next level up, response to the stress. Chronic stress can lead to anxiety disorders.

Some estimates put it as high as 30 percent for those with anxiety that choose to forgo treatment. Recent studies suggest that not only is there a human cost to anxiety disorders, but an economic one, “owing to lost work productivity and high medical resource use.” Anxiety is real, and its increasingly a cause of concern.

cannabis, anxious, anxiety attack, panic attack, mental health, cannabinoids, terpenes, health benefits, entourage effect, endocannabinoid system

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There is a rising tide of people seeking alternative therapies for their anxiety. They may have tried pharmaceuticals only to be locked out from feeling anything at all. Anti-anxiety medications tend to flatline you and numb your emotions. This can be good for a crisis, but it’s no long term solution. Cannabis is a viable option for treating anxiety. Of particular interest are the non-psychoactive components of this plant, which include cannabinoids and terpenes.

Terpenes are the new frontier of cannabis medicine. Terpenes are the essential oils; the aromatic compounds that fulfill the experience of cannabis with flavor and aroma. But, did you know that they also have incredible medicinal benefit? Experts now believe terpenes have potential as a new treatment for anxiety, and mental health more generally.

cannabis, anxiety, anxious, panic attack, relaxed, terpenes, cannabinoids, endocannabinoid system, mental health, legalization, entourage effect

Image credit: Alena Ozerova

What Does the Research Say So Far?

A new study, Cannabis and the Anxiety of Fragmentation – A Systems Approach for Finding an Anxiolytic Cannabis Chemotype, will lay the groundwork for a systematic analysis of which compounds in cannabis trigger anxiety and which reduce it. This study is so new, it’s not available in full. However, the summary suggests at least one terpene – trans-nerolidol – has massive potential.

Trans-nerolidol is a secondary terpene in cannabis, but very prominent in other aromatic plants like jasmine, lemongrass and tea tree. Common strains with high trans-nerolidol levels are the include Jack Herer and Island Sweet Skunk. Trans-nerolidol produces a gentle floral aroma, which is often compared to apples, roses, and sweet fruits.

Another hot terpene for anxiety is limonene, usually found in higher quantities than trans-nerolidol. Top strains with limonene include Jack Herer, Super-lemon Haze and Berry White. Limonene is a citrusy scent, also found in oranges, lemons, and grapefruits.

A recent publication from a 2012 issue of Brain Research, found measurable effects for reducing animal models of anxiety. The study concludes, “that acute administration of the (+)-limonene epoxide exerts an anxiolytic-like [anti-anxiety] effect on mice, and it could serve as a new approach for the treatment anxiety, since it practically does not produce toxic effects.”

The other medicinal benefits of limonene.

There are hints that myrcene, a primary cannabinoid in cannabis, may also lend itself to anxiety reduction – although the evidence is less clear cut. In one study, essential oils containing myrcene reduced anxiety and elevated mood in a dentist’s office. In another study, orange essential oil (which contains myrcene) was used to reduce anxiety in mice. In both cases, myrcene was not the primary compound under investigation, nor were the essential oils from cannabis, but this preliminary support may lead to more scientific exploration going forward.

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Image credit: The Leaf Online

Terpenes, Entourage Effect, and Anxiety

Although the evidence supports the use of individual cannabinoids and terpenes, like CBD and limonene, for use as novel new approaches to anxiety, part of the beauty of cannabis is that they often come together in the natural plant in a way that enhances the benefit of any single component.

Cannabis contains hundreds of compounds; over 100 known cannabinoids, and perhaps as many as 200 terpenes. Each of these works with our body in a different way, as well as working with each other. The little understood synergistic relationship between cannabinoids and terpenes is called the Entourage Effect. The theory goes that while each compound may be beneficial, they are exponentially more useful when used together.

cannabis, terpenes, entourage effect, myrcene, limonene, trans-nerolidol, anxiety, mental health, panic attack, legalization

Image credit: Brandon Crawford

Given a little more time and a better understanding of the hundreds of cannabinoids and terpenes found in cannabis, cultivators may be able to breed the perfect strain of cannabis for anxiety.

The ultimate? A strain with high levels of myrcene, limonene, and trans-nerolidol combined with lots of CBD and low levels of THC. Cannabis may be the future of natural anxiety meds.






Jessica McKeil
Jessica McKeil

Jessica McKeil is a freelance writer focused on the medical marijuana industry, from production methods to medicinal applications. She is lucky enough to live in beautiful British Columbia, Canada where the cannabis industry is exploding. When not writing, she spends much of her time exploring in the coastal forests.

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    Dwight butler

    Love everything that you do

    March 15, 2019 at 12:02 pm Reply
    • Jennifer Grant

      Thanks Dwight! Love that you are here with us.

      March 15, 2019 at 9:09 pm Reply
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    Jacqueline Lockard

    I need something to helpy moods. High Anxiety.mamic times panic Attacks.I hate all of the sitomes.can it helpe me I feel like my brain is running me and I can’t control the thought s.but at times I will come up with great thoughts if I had money I would be a billionaire.with great ideas..I think I have (sad) I have all the siptomes.I all so have chronic pain in my lower left hip.legs.neck I have two rods in my back.I could go on but then I would be writing you a book of my crazy life.I have been trying to come up with the money to be seen by your Drs.3of my Drs recamend this that you can help me but I’m on SSI fixed income so coming up with 150.00 pluse the cost of the medicine how do I come.up with it Mom of seven Jacqueline fill crazy. Am i

    July 23, 2019 at 7:33 am Reply
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    tom krynock

    Interested in the effects of terpenes

    September 17, 2019 at 4:47 am Reply

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