More patients than ever are trying cannabis for neuropathic pain and meeting with successful relief of painful symptoms.
Neuropathic Pain Caused by Injury
Broken or dislocated bones
Injury to tissue, muscles, or joints
Neuropathic Pain Caused by Disease
carpal tunnel syndrome,
and even vitamin B deficiency.
Symptoms of Neuropathy
Treating Neuropathy With Pharmaceuticals
How Cannabis May Treat Neuropathic Pain
The Role of the Endocannabinoid System in Pain Management
Cannabis and The ECS
Relieving Neuropathic Pain
For example, a study published in Neurology (2018)Weizman, Libat, et al. “Cannabis Analgesia in Chronic Neuropathic Pain Is Associated with Altered Brain Connectivity.” Neurology, Wolters Kluwer Health, Inc. on Behalf of the American Academy of … Continue readinginvestigated how THC could help fifteen male patients with chronic nerve pain. They each underwent an MRI brain scan, and then were dosed with fifteen milligrams of THC. Two hours later, researchers gave the subjects another MRI. They found that not only did THC help alleviate pain, but the patients actually self-ranked their discomfort nearly twenty points lower on a one-hundred point scale. Through the MRI, the scientists discovered that THC changed the connections in the brain that were responsible for processing pain sensations.
Cannabinoids in Conjunction
Multiple cannabinoids are now under study for their effects on fixing neuropathic pain. Of particular interest is how they work together to fight pain. Here’s an example: the intersection of cannabis, nerve injury, and inflammation. THC activates the patient’s receptors, thus alleviating nerve pain. But at the same time, CBD can also help reduce inflammation, which is a common cause of nerve pain due to the narrowing of nerve pathways. Basically, by inhibiting a non-cannabinoid receptor called GPR55, it induces an anti-inflammatory effect.
Study on CBD and Neuropathy
Cannabis Vs Opioids? Or Cannabis And Opioids?
Cannabis and Quality of Life For Neuropathy Patients
Other Cannabis Compounds for Potential Pain Relief
|↑1||Hecke, O. van, et al. “Neuropathic Pain in the General Population: A Systematic Review of Epidemiological Studies.” PAIN®, No Longer Published by Elsevier, 26 Nov. 2013,www.sciencedirect.com/science/article/abs/pii/S0304395913006106.|
|↑2||Donvito, Giulia, Sara Nass, et al. “The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.” Neuropsychopharmacology, 2018,www.nature.com/articles/npp2017204.pdf.|
|↑3||Weizman, Libat, et al. “Cannabis Analgesia in Chronic Neuropathic Pain Is Associated with Altered Brain Connectivity.” Neurology, Wolters Kluwer Health, Inc. on Behalf of the American Academy of Neurology, 2 Oct. 2018,n.neurology.org/content/91/14/e1285.|
|↑4||Xu, Dixon H, et al. “The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities.” Current Pharmaceutical Biotechnology, U.S. National Library of Medicine, 1 Dec. 2019,www.ncbi.nlm.nih.gov/pubmed/31793418.|
|↑5||Khasabova, Iryna A, et al. “CB1 And CB2 Receptor Agonists Promote Analgesia through Synergy in a Murine Model of Tumor Pain.” Behavioural Pharmacology, U.S. National Library of Medicine, Sept. 2011,www.ncbi.nlm.nih.gov/pmc/articles/PMC3155626/.|
|↑6||Wallace, Mark S, et al. “Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy.” The Journal of Pain : Official Journal of the American Pain Society, U.S. National Library of Medicine, July 2015,www.ncbi.nlm.nih.gov/pmc/articles/PMC5152762/.|
|↑7||Aviram, J, and G Samuelly-Leichtag. “Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Pain Physician, U.S. National Library of Medicine, Sept. 2017,www.ncbi.nlm.nih.gov/pubmed/28934780.|