The CBC Cannabinoid That Could Work For: Pain Relief, Tumor Suppression, Anti-Acne, Anti-Depressive, Antibacterial Action
Cell studies have demonstrated that CBC could function like THC in killing cancer cells, and that’s just for starters.
Cannabichromene (CBC) is an up and coming on the medical scene, but it is still sparse on official research. This is slowly changing as we come to recognize the medicinal benefit of CBC cannabinoid. It is among the “big six” cannabinoids derived from cannabis and as research is proving, it is definitely a force to reckon with.
THC and CBD are the most well known of cannabinoids, and have the same precursor as CBC; that is cannabigerolic acid (CBGA). In the formation of CBC, CBGA is broken down into cannabichrome carboxylic acid (CBCA) which, when exposed to light, breaks down into CBC.
This is How CBC works
CBC is non-psychoactive, meaning that it does not produce feelings of euphoria. This is a result of its poor affinity for the CB1 receptor. This cannabinoid does, however, bind well to the vanilloid receptor 1 (TRPV1) and another transient receptor potential ankyrin 1 (TRPA1), both of which are strongly linked to the perception of pain.
When CBC binds to these receptors, it activates the body’s natural endocannabinoids, such as anandamide. Where CBC indirectly activates the cannabinoid receptors, THC and other psychoactive compounds bind to, and directly activate, CB1 and CB2. All contribute to the result of pain relief.
CBC also acts synergistically with other cannabinoids, terpenes, and flavonoids, which results in a stronger and more potent effect, owing to the entourage effect. Here are some of the known medicinal benefits associated with CBC:
CBC inhibits the uptake of anandamide, meaning that anandamide stays for longer periods of time within the blood stream. This cannabinoids has been shown to be effective against breast cancer, both in vivo and in vitro. A study conducted in 2006 showed the effectiveness of cannabinoids other than THC in suppressing cancer cells; it was shown that CBC is the second most powerful cannabinoid in fighting cancer.
Image credit: ESB Professional
CBC is effective in suppressing inflammation, such as that seen in osteoarthritis. In combination with THC, CBC has a stronger effect on pain control. Unlike NSAIDs, which also fight inflammatory pain, CBC is not associated with ulcerative disease when used for a long duration.
Promotes Healthy Brain Function
CBC has been shown to have positive effects on neurogenesis by promoting neural stem progenitor cell activity. These progenitor cells show more viability in the presence of CBC and this is vital for brain homeostasis and proper functioning. The cells further differentiate into astroglia cells. The astroglia cells counteract issues, such as oxidative stress, which can lead to inflammation and finally, neurological pathologies, such as Alzheimer’s disease.
Results from a 2016 study revealed that CBC is effective in the treatment of acne. Acne is characterized by excessive sebum production and the inflammation of sebaceous glands. CBC was shown to fight inflammation and to suppress the production of sebum. Further research is needed to confirm this findings as CBC can be a powerful remedy against acne.
CBC is able to amplify the potency of THC and CBD in the treatment of depression. This is as a result of the entourage effect which also includes terpenes, flavanoids and other cannabinoids working together synergistically.
A study conducted way back in the 1980s showed the efficacy of CBC cannabinoid as a potent antibacterial agent. CBC was able to combat both gram positive and gram negative bacteria, such as S. aureus and E. coli.
Another study, conducted in 2008, demonstrated that CBC cannabinoid was effective against the stubborn MRSA strain. Compared to other drugs that fight MRSA, such as vancomycin, CBC has less adverse effects and is a much safer medicine.
At the start of the 21st century, a June 2011 study investigated CBC together with other cannabinoids as an antidepressant. In November 2010, another study evaluated the potency of CBC as an anti inflammatory, and a similar study was carried out in February 2011. The next year, a study was conducted to investigate the effect of CBC on gastric motility and in 2003 another study investigated the effect of CBC on neurogenesis. The most recent study was conducted in September 2016 and it revealed the positive effects of CBC in fighting acne.
The potential medicinal benefits of the CBC cannabinoid are only just beginning to be understood. There are uses for CBC as a stand alone medicine and as a part of the synergistic effects of whole plant medicine. More money and effort need to be invested into researching CBC for cancer and other ailments.