Wax On Wax Off: How Worried Should You Be About Contaminants in Concentrates? - RxLeaf
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Wax On Wax Off: How Worried Should You Be About Contaminants in Concentrates?

Randy Robinson
cannabis, rosin press, cannabis concentrates, wax, budder, CBD, THC, purity, vaping, dabbing

Toxins in concentrates are a big concern, these can even block CBD’s medicinal ability to stop seizure activity! How do you protect yourself from concentrates that are bad for you?

Concentrates, also known as dabs, are quickly overtaking edibles as everyone’s second-favorite cannabis product. Although the rapidly rising popularity of concentrates may sound awesome, we still don’t know what the long-term effects of dabbing are.

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Concentrates, like any processed product, may be contaminated. Waxes extracted with hydrocarbons (like butane or propane) will contain residues of volatile solvents. Even solventless concentrates, like rosin, will generate toxic compounds when vaporized or combusted. And as commercial grow operations increasingly rely on pesticides, herbicides, and other poisons to protect their crops, the risk of those poisons transferring into concentrates has concerned regulators and consumers.

What sorts of contaminants may be present in concentrates, and should you be concerned about them?

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Silent Killers: Pesticides, Herbicides, and Fungicides

A couple of years ago, the U.S.’s premier chemistry organization, the American Chemical Society, formed its Cannabis Chemistry Subdivision to study our favorite plant. Kyle Boyar is a San Diego-based neuroscientist and analytical chemist at the ACS, and for the past year he has served as the chair of the subdivision’s scholarship committee, where he awards grants to laboratories that conduct cannabis research.

When asked about pesticide contamination in concentrates, he told RxLeaf by phone, “It’s a huge problem here in California.”

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Boyar noted that there are several ways to clean up concentrates to remove things like herbicides and pesticides from the final product. Contamination can occur through multiple routes, but one of the most common ways is through contamination of the extraction machines themselves.

“Let’s say you get a contaminated batch of trim – it could be Eagle-20, or it could be a million different pesticides in there – and you run it through your closed loop extraction instrument,” he explained. “What you’ve just done is contaminated your entire instrument. Now, all of your subsequent extractions will be contaminated with those pesticides, because you processed dirty material.”

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Image credit: Leafly

There is hope, however. Boyar added, “There are preventative measures people do take, and there are people, especially in the legal markets, to eliminate those problems downstream.”

One of those measures is processing plant material from trusted sources. Hygienic extraction labs will regularly test batches of plant material and their instruments to ensure pesticide, herbicide, and other nasty residues don’t get stuck to the interiors of columns and tanks.

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Fuel Sources: Hydrocarbon Solvents

Most concentrates are extracted with hydrocarbons such as butane and propane, organic compounds that are both incredibly volatile and insidiously toxic in high amounts. Legal weed states require processors to purge concentrates with heat and vacuum filtration, but these processes always leave some residual solvent in the oil.

When asked if butane or propane residues should worry cannabis consumers, he replied, “In my personal opinion: No. If you’re worried about it, you probably shouldn’t be consuming it anyway.”

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According to Boyar, pot smokers inhale more butane from a lighter hitting a glass pipe than they ever would from “the dirtiest concentrate.”

“The tolerance for something like that is very high,” he said. “You’d have to be inhaling tons of it, enough to visibly see it, for it to be a problem.”

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Under the Radar: Mycotoxins

Although Boyar believes most cannabis labs properly screen for the obvious contaminants, there is one potential issue that no one’s talking about: mycotoxins

Mycotoxins are toxic metabolites produced by fungi. In 2016, one study found that cannabis samples sold in Amsterdam and Massachusetts were contaminated with Penicillium. Penicillium, the fungus we get penicillin from, also produces a mycotoxin called paxilline. Paxilline can trigger tremors, and it can block CBD’s ability to stop seizures.

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“It has profound implications for people who are epileptic,” Boyar warned, largely because compounds like paxilline cannot be easily removed from concentrates. “Mycotoxins are incredibly stable. They’re resistant to heat, and you can’t get rid of them with distillation.”

Unfortunately, the prevalence of mycotoxin contamination is unknown. Boyar said there isn’t enough data right now because most labs don’t test for mycotoxins, and the ones that do only screen for “a handful.”

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Double-Edged Sword: Terpene Degradation Products

Another danger from concentrates isn’t exactly contamination. Rather, it’s a consequence of dabbing based on the plant’s natural chemistry.

We often talk about terpenes as the next big trend in cannabis, whether medicinal or recreational. Terpenes are aromatic compounds that give cannabis its unique flavor and bouquets, and there’s some evidence that terpenes may determine what kinds of highs we experience, too.

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However, some terpenes have some downsides. Pinene, a terpene that smells like pine needles and can act as a nervous system stimulant, can irritate tissues in small amounts. Massive doses of pinene can trigger seizures in susceptible individuals.

Most concentrates, thankfully, will never deliver the amount of terpenes to make them dangerous. But heating and combustion of terpenes can degrade these tasty molecules into carcinogens and neurotoxins.

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Last year, Robert Strongin’s research group at Portland State University in Oregon looked at terpene degradation from dabbing. The study, published in ACS Omega, mimicked conventional dabbing by dropping concentrates onto heated nails, pulling the vapor through a water filter, then chemically analyzing the vapor’s contents at the other end.

One of the major terpene degradation products Strongin’s group detected was methacrolein. Methacrolein, also known as methacrylaldehyde, can irritate the eyes and respiratory system. Its formation during dabbing may explain why dabs cause some people to cough and tear up more than smoking does.

Another terpene degradation product generated by dabbing is benzene, one of the chemicals that makes tobacco smoke highly carcinogenic.

“Terpenes are ubiquitous in our environment,” Strongin said over the phone. “Their degradation pathways are very well known. What we saw was really no surprise.”

Strongin noted that terpene degradation products aren’t just produced from dabbing. Smoking cannabis also generates these nasty little molecules, too.

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Strongin stressed that he was not a medical doctor and could not give medical advice. He did, however, suggest cannabis consumers should “dab at lower temperatures with as much control as you can.”

That means don’t hit the rig when the nail is still red hot. If the nail features temperature settings, he said it’s wise to use the lowest setting possible.

“Any level of benzene is bad,” Strongin said, “but the lower the temperature, the more likely you are to limit your exposure.”

 

Randy Robinson

As someone who wanted to know everything but couldn't decide on anything, Randy completed degrees in English, World History, and Molecular Biology. During their studies, they received an externship at the biotech firm Cannabis Science Inc., focusing on phytocannabinoids as anti-tumor and anti-cancer agents. Based in the Mile High City of Denver, Colorado, you can find Randy on Twitter, Instagram, and Medium @RanDieselJay

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